The obesity epidemic otherwise known as “adiposity-based chronic disease” has become the most important public health issue of our time. Despite efforts to limit caloric intake, promote exercise and heighten awareness, the numbers of affected individuals continue to grow exponentially. Despite decades old research and new insights into the biological/genetic causation of the disease, health care providers are reluctant to abandon the often dangerous and ineffective dictum of “diet and exercise” prescription to combat a problem of self-control. Despite the effectiveness of surgical interventions; they are costly and cannot be applied to the masses. However, analysis of the pathophysiology of our interventions can provide insight into non-invasive or preventive measures that can be adopted globally